Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62001

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dc.contributor.authorYamane, L. S.por
dc.contributor.authorScapulatempo-Neto, C.por
dc.contributor.authorAlvarenga, L.por
dc.contributor.authorOliveira, C. Z.por
dc.contributor.authorBerardinelli, G. N.por
dc.contributor.authorAlmodova, E.por
dc.contributor.authorCunha, T. R.por
dc.contributor.authorFava, G.por
dc.contributor.authorColaiacovo, W.por
dc.contributor.authorMelani, A.por
dc.contributor.authorFregnani, J. H.por
dc.contributor.authorReis, R. M.por
dc.contributor.authorGuimarães, D. P.por
dc.date.accessioned2019-11-08T17:02:57Z-
dc.date.issued2014-10-
dc.identifier.citationYamane, L. S., Scapulatempo-Neto, C., Alvarenga, L., Oliveira, C. Z., Berardinelli, G. N., Almodova, E., ... & Fregnani, J. H. (2014). KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy. Oncology reports, 32(4), 1419-1426por
dc.identifier.issn1021-335X-
dc.identifier.urihttp://hdl.handle.net/1822/62001-
dc.description.abstractColorectal cancer (CRC) is one of the most frequent cancers worldwide. Adenoma is the main precursor lesion and, recently, the serrated polyps were described as a group of colorectal lesions with malignant potential. The morphologic and biologic characterizations of serrated polyps remain limited. The aim of the present study was to determine the frequency of KRAS and BRAF mutations and microsatellite instability (MSI) in CRC precursor lesions, to evaluate the association between molecular, pathologic and morphologic alterations in precursor lesions and to compare with the alterations detected in CRC. A series of 342 precursor lesions were removed from 155 patients during colonoscopy. After morphologic classification, molecular analysis was performed in 103 precursor lesions, and their genetic profile compared with 47 sporadic CRCs. Adenomas were the main precursor lesions (70.2%). Among the serrated polyps, the main precursor lesion was hyperplastic polyps (HPs) (82.4%), followed by sessile serrated adenomas (12.7%) and traditional serrated adenomas (2.0%). KRAS mutations were detected in 13.6% of the precursor lesions, namely in adenomas and in HPs, but in no serrated adenoma. BRAF mutations were found in 9 (8.7%) precursor lesions, mainly associated with serrated polyps and absent in adenomas (P<0.001). High MSI (MSI-H) was absent in precursor lesions. In the 47 CCR cases, 46.8% exhibited KRAS mutation, 6.5% BRAF mutations and 10.6% MSI-H. This study confirms the role of KRAS and BRAF mutations in CRC carcinogenesis, a crucial step in implementing CRC screening strategies.por
dc.language.isoengpor
dc.publisherSpandidos Publicationspor
dc.rightsrestrictedAccesspor
dc.subjectAdenocarcinomapor
dc.subjectAdenomapor
dc.subjectAgedpor
dc.subjectAged, 80 and overpor
dc.subjectColonic Polypspor
dc.subjectColonoscopypor
dc.subjectColorectal Neoplasmspor
dc.subjectFemalepor
dc.subjectHumanspor
dc.subjectMalepor
dc.subjectMiddle Agedpor
dc.subjectMutationpor
dc.subjectProto-Oncogene Proteinspor
dc.subjectProto-Oncogene Proteins B-rafpor
dc.subjectProto-Oncogene Proteins p21(ras)por
dc.subjectras Proteinspor
dc.subjectMicrosatellite Instabilitypor
dc.subjectserrated polyppor
dc.subjectKRASpor
dc.subjectBRAFpor
dc.subjectcolorectal cancerpor
dc.titleKRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopypor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.spandidos-publications.com/10.3892/or.2014.3338por
oaire.citationStartPage1419por
oaire.citationEndPage1426por
oaire.citationIssue4por
oaire.citationVolume32por
dc.identifier.essn1791-2431-
dc.identifier.doi10.3892/or.2014.3338por
dc.date.embargo10000-01-01-
dc.identifier.pmid25050586por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalOncology Reportspor
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