Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61994
Título: | In search of a new paradigm for protective immunity to TB |
Autor(es): | Nunes-Alves, Cláudio Booty, Matthew G. Carpenter, Stephen M. Jayaraman, Pushpa Rothchild, Alissa C. Behar, Samuel M. |
Palavras-chave: | Biomarkers Clinical Trials as Topic Humans Mycobacterium tuberculosis Tuberculosis Tuberculosis Vaccines |
Data: | 2014 |
Editora: | Nature Research |
Revista: | Nature Reviews Microbiology |
Citação: | Nunes-Alves, C., Booty, M. G., Carpenter, S. M., Jayaraman, P., Rothchild, A. C., & Behar, S. M. (2014). In search of a new paradigm for protective immunity to TB. Nature Reviews Microbiology, 12(4), 289-299. |
Resumo(s): | Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and results are starting to come in. Some of these results are not so encouraging, as exemplified by the latest Aeras-422 and MVA85A trials. Other than empirically determining whether a vaccine reduces the number of cases of active tuberculosis, which is a daunting prospect given the chronic nature of the disease, we have no way of assessing vaccine efficacy. Therefore, investigators seek to identify biomarkers that predict vaccine efficacy. Historically, focus has been on the production of interferon-γ by CD4(+) T cells, but this has not been a useful correlate of vaccine-induced protection. In this Opinion article, we discuss recent advances in our understanding of the immune control of M. tuberculosis and how this knowledge could be used for vaccine design and evaluation. |
Tipo: | Artigo |
Descrição: | Author Manuscript |
URI: | https://hdl.handle.net/1822/61994 |
DOI: | 10.1038/nrmicro3230 |
ISSN: | 1740-1526 |
e-ISSN: | 1740-1534 |
Versão da editora: | https://www.nature.com/articles/nrmicro3230 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Nunes-alves-2014-In-search-of-a-new-paradigm-for-pro.pdf Acesso restrito! | 832,12 kB | Adobe PDF | Ver/Abrir |