Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61697
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Campo DC | Valor | Idioma |
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dc.contributor.author | Barbosa, Thallysson Carvalho | por |
dc.contributor.author | Nascimento, Lívia Éven Dias | por |
dc.contributor.author | Bani, Cristiane | por |
dc.contributor.author | Almeida, Taline | por |
dc.contributor.author | Nery, Marcelo | por |
dc.contributor.author | Santos, Rafael Silva | por |
dc.contributor.author | Menezes, Luana Renyelle de Oliveira | por |
dc.contributor.author | Zielinska, Aleksandra | por |
dc.contributor.author | Fernandes, Ana Rita | por |
dc.contributor.author | Cardoso, Juliana Cordeiro | por |
dc.contributor.author | Jäguer, Alessandro | por |
dc.contributor.author | Jäguer, Eliezer | por |
dc.contributor.author | Sanchez-Lopez, Elena | por |
dc.contributor.author | Nalone, Luciana | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Severino, Patrícia | por |
dc.date.accessioned | 2019-10-10T11:05:24Z | - |
dc.date.available | 2019-10-10T11:05:24Z | - |
dc.date.issued | 2019-09-22 | - |
dc.identifier.citation | Barbosa, Thallysson Carvalho; Nascimento, Lívia Éven Dias; Bani, Cristiane; Almeida, Taline; Nery, Marcelo; Santos, Rafael Silva; Menezes, Luana Renyelle de Oliveira; Zielinska, Aleksandra; Fernandes, Ana Rita; Cardoso, Juliana Cordeiro; Jäguer, Alessandro; Jäguer, Eliezer; Sanchez-Lopez, Elena; Nalone, Luciana; Souto, Eliana; Severino, Patrícia, Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(-caprolactone) nanocapsules. Toxics, 7(4), 51, 2019 | por |
dc.identifier.issn | 2305-6304 | por |
dc.identifier.uri | https://hdl.handle.net/1822/61697 | - |
dc.description.abstract | The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen’s egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3. | por |
dc.description.sponsorship | This research was funded by Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was also financed through the project M-ERA-NET/0004/2015 and scholarship grant SFRH/BD/130555/2017, from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) from national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI AG | por |
dc.relation | SFRH/BD/130555/2017 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | polymeric nanocapsules | por |
dc.subject | poly(e-caprolactone) | por |
dc.subject | benzophenone-3 | por |
dc.subject | sunscreen | por |
dc.subject | cytotoxicity | por |
dc.subject | ocular tolerance | por |
dc.subject | poly(epsilon-caprolactone) | por |
dc.subject | Poly(ε-caprolactone) | por |
dc.title | Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(-caprolactone) nanocapsules | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2305-6304/7/4/51 | por |
dc.comments | CEB52031 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2019-09-28T12:36:04Z | - |
dc.identifier.eissn | 2305-6304 | por |
dc.identifier.doi | 10.3390/toxics7040051 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Toxics | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_52031_1.pdf | 2,44 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons