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TitleDevelopment, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(-caprolactone) nanocapsules
Author(s)Barbosa, Thallysson Carvalho
Nascimento, Lívia Éven Dias
Bani, Cristiane
Almeida, Taline
Nery, Marcelo
Santos, Rafael Silva
Menezes, Luana Renyelle de Oliveira
Zielinska, Aleksandra
Fernandes, Ana Rita
Cardoso, Juliana Cordeiro
Jäguer, Alessandro
Jäguer, Eliezer
Sanchez-Lopez, Elena
Nalone, Luciana
Souto, Eliana
Severino, Patrícia
Keywordspolymeric nanocapsules
ocular tolerance
Issue date22-Sep-2019
PublisherMDPI AG
CitationBarbosa, Thallysson Carvalho; Nascimento, Lívia Éven Dias; Bani, Cristiane; Almeida, Taline; Nery, Marcelo; Santos, Rafael Silva; Menezes, Luana Renyelle de Oliveira; Zielinska, Aleksandra; Fernandes, Ana Rita; Cardoso, Juliana Cordeiro; Jäguer, Alessandro; Jäguer, Eliezer; Sanchez-Lopez, Elena; Nalone, Luciana; Souto, Eliana; Severino, Patrícia, Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(-caprolactone) nanocapsules. Toxics, 7(4), 51, 2019
Abstract(s)The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen’s egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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