Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61640

TitleLipocalin 2 is a choroid plexus acute-phase protein
Author(s)Marques, Fernanda
Rodrigues, Ana João
Sousa, João Carlos
Coppola, Giovanni
Geschwind, Daniel H.
Sousa, Nuno
Correia-Neves, M
Palha, Joana Almeida
KeywordsAcute-Phase Proteins
Animals
Cerebrospinal Fluid
Choroid Plexus
Humans
Inflammation
Lipocalin-2
Lipocalins
Lipopolysaccharides
Male
Mice
Mice, Inbred C57BL
Oncogene Proteins
RNA, Messenger
Up-Regulation
Immunity, Innate
Lipocalin
Lipocalin
Lipopolysaccharide
Siderophore
iron
Issue dateMar-2008
PublisherSAGE Publications
JournalJournal of Cerebral Blood Flow and Metabolism
CitationMarques, F., Rodrigues, A. J., Sousa, J. C., Coppola, G., Geschwind, D. H., Sousa, N., ... & Palha, J. A. (2008). Lipocalin 2 is a choroid plexus acute-phase protein. Journal of Cerebral Blood Flow & Metabolism, 28(3), 450-455.
Abstract(s)Lipocalin 2 (LCN2) is able to sequester iron-loaded bacterial siderophores and, therefore, is known to participate in the mammalian innate immune response. Of notice, LCN2 was shown to display bacteriostatic effects both in in vitro and in vivo. To reach the brain, bacteria must cross the blood-brain or the choroid plexus (CP)/cerebrospinal fluid (CSF) barriers. Additionally, as the CP is responsible for the production of most of the CSF, responses of the CP mediate signaling into the brain. We show here that in conditions of peripheral inflammation, LCN2 behaves as an acute phase protein in the CP. As early as 1 h after lipopolysaccharide peripheral administration, Lcn2 mRNA levels are upregulated, returning to basal levels after 72 h. Increased LCN2 protein is observed in choroidal epithelia and in endothelial cells of blood vessels in the brain parenchyma. Higher levels of LCN2 are also present in the CSF. These observations suggest that expression of LCN2 at the CP/CSF barrier might be bacteriostatic in the brain, avoiding bacteria dissemination within the CSF into the brain parenchyma. This study shows that the LCN2 is produced by the CP as a component of the innate immune response that protects the central nervous system from infection.
TypeArticle
URIhttp://hdl.handle.net/1822/61640
DOI10.1038/sj.jcbfm.9600557
ISSN0271-678X
e-ISSN1559-7016
Publisher versionhttps://journals.sagepub.com/doi/full/10.1038/sj.jcbfm.9600557
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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