Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61633

TitleDecreased serum neurotrophin 3 in chronically medicated schizophrenic males
Author(s)Vargas, Haroldo Evangelista
Gama, Clarissa Severino
Andreazza, Ana Cristina
Medeiros, Dalton
Stertz, Laura
Fries, Gabriel
Palha, Joana Almeida
Cereser, Keila Maria
Berk, Michael
Kapczinski, Flavio
Belmonte-de-Abreu, Paulo Silva
KeywordsAdult
Antipsychotic Agents
Clozapine
Diagnostic and Statistical Manual of Mental Disorders
Enzyme-Linked Immunosorbent Assay
Haloperidol
Humans
Longitudinal Studies
Male
Middle Aged
Neurotrophin 3
Phlebotomy
Risperidone
Schizophrenia
Neurotrophins
NT3
BDNF
Antipsychotics
Issue date8-Aug-2008
PublisherElsevier
JournalNeuroscience Letters
Abstract(s)There is evidence that major psychiatric disorders such as schizophrenia (SZ) are associated with deregulation of synaptic plasticity with downstream alterations of neurotrophins. NT3 is an important neurotrophin in the central nervous system, and performs key biological functions, such as promoting the survival, differentiation, and plasticity of neurons. NT3 has a central role in the early neuronal development; enhancing the survival of dopaminergic neurons, suggesting possible involvement in the physiopathology of dopamine related neuropsychiatric disorders such as SZ. Variations in the NT3 gene increase the risk of SZ. Three groups of chronically medicated DSM-IV patients with SZ, on treatment with clozapine (n=12), haloperidol (n=12), risperidone (n=12) and 10 healthy controls had 5 ml blood samples collected by venipuncture. NT3 serum levels were assessed using sandwich-ELISA and were significantly lower in SZ patients (p<0.005) when compared to either controls. These findings suggest that the NT3 signaling system may play a role in the pathophysiology of SZ and might be related to the course of illness or to treatment variables. Longitudinal studies are warranted.
TypeArticle
URIhttp://hdl.handle.net/1822/61633
DOI10.1016/j.neulet.2008.04.027
ISSN0304-3940
e-ISSN1872-7972
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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