Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61628

TitleStress and glucocorticoid footprints in the brain-the path from depression to Alzheimer's disease
Author(s)Sotiropoulos, I.
Cerqueira, João José
Catania, C.
Takashima, A.
Sousa, Nuno
Almeida, O. F. X.
KeywordsAlzheimer Disease
Animals
Brain
Depressive Disorder
Glucocorticoids
Humans
Stress, Physiological
Sex
Mood
Cognition
Depression
stress
Alzheimer's disease
Issue dateAug-2008
PublisherElsevier
JournalNeuroscience and Biobehavioral Reviews
CitationSotiropoulos, I., Cerqueira, J. J., Catania, C., Takashima, A., Sousa, N., & Almeida, O. F. X. (2008). Stress and glucocorticoid footprints in the brain—the path from depression to Alzheimer's disease. Neuroscience & Biobehavioral Reviews, 32(6), 1161-1173
Abstract(s)Increasingly, stress is recognized as a trigger of depressive episodes and recent evidence suggests a causal role of stress in the onset and progression of Alzheimer's disease (AD) pathology. Besides aging, sex is an important determinant of prevalence rates for both AD and mood disorders. In light of a recent meta-analysis indicating that depressed subjects have a higher likelihood of developing AD, a key message in this article will be that both depression and AD are stress-related disorders and may represent a continuum that should receive more attention in future neurobiological studies. Accordingly, this review considers some of the cellular mechanisms that may be involved in regulating this transition threshold. In addition, it highlights the importance of addressing the question of how aging and sex interplay with stress to influence mood and cognition, with a bias towards consideration of neuroplastic events in particular brain regions, as the basis of AD and depressive disorders.
TypeArticle
URIhttp://hdl.handle.net/1822/61628
DOI10.1016/j.neubiorev.2008.05.007
ISSN0149-7634
e-ISSN1873-7528
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0149763408000705
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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