Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61605

TitleInduction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis
Author(s)Macedo, Francisco Yuri Bulcão
Baltazar, Fátima
Mourão, Lívia Cajaseiras
Almeida, Paulo Roberto Carvalho
Mota, José Mauricio S. C.
Schmitt, Fernando C.
Ribeiro, Ronaldo A.
KeywordsAcrolein
Administration, Intravesical
Animals
Cyclooxygenase-2
Cystitis
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Induction
Hemorrhage
Male
Organ Size
Rats
Rats, Wistar
Time Factors
Urinary Bladder
Hemorrhagic cystitis
Issue dateApr-2008
PublisherElsevier
JournalExperimental and Toxicologic Pathology
Abstract(s)Aim: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HC), induced by these compounds. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC. Methods: Male Wistar rats (150–200 g; six rats per group) were treated with distilled water or intravesical ACR and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters and COX-2 expression. Results: COX-2 immunohistochemical expression was significant 12 h after ACR administration mainly in subepithelial cells. ACR injection also alters some macroscopic and microscopic parameters in bladder of rats analyzed by Gray’s criteria. Conclusions: COX-2 participates in the pathogenesis of ACR-induced HC first seen 12 h after initial contact between ACR and urothelium.
TypeArticle
URIhttp://hdl.handle.net/1822/61605
DOI10.1016/j.etp.2007.10.010
ISSN0940-2993
e-ISSN1618-1433
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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