Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61600
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gama, Adelina | por |
dc.contributor.author | Paredes, Joana | por |
dc.contributor.author | Gärtner, Fátima | por |
dc.contributor.author | Alves, Anabela | por |
dc.contributor.author | Schmitt, Fernando | por |
dc.date.accessioned | 2019-10-04T10:29:02Z | - |
dc.date.available | 2019-10-04T10:29:02Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 1090-0233 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61600 | - |
dc.description.abstract | Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression. | por |
dc.description.sponsorship | This work was supported by the Centro de Ciência Animal e Veterinária (CECAV) – University of Trás os Montes e Alto Douro (UTAD), Vila Real, Portugal and by Portuguese Science and Technology Foundation, Project POCTI/CVT/57795/2004. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/57795/PT | por |
dc.rights | openAccess | por |
dc.subject | Animals | por |
dc.subject | Biomarkers, Tumor | por |
dc.subject | Cadherins | por |
dc.subject | Disease-Free Survival | por |
dc.subject | Dog Diseases | por |
dc.subject | Dogs | por |
dc.subject | Female | por |
dc.subject | Immunohistochemistry | por |
dc.subject | Lymph Nodes | por |
dc.subject | Lymphatic Metastasis | por |
dc.subject | Mammary Neoplasms, Animal | por |
dc.subject | Neoplasm Invasiveness | por |
dc.subject | Prognosis | por |
dc.subject | Survival Analysis | por |
dc.subject | Beta Catenin | por |
dc.subject | Gene Expression Regulation, Neoplastic | por |
dc.subject | Canine | por |
dc.subject | Mammary tumours | por |
dc.subject | E-cadherin | por |
dc.subject | P-cadherin | por |
dc.subject | β-Catenin | por |
dc.title | Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 45 | por |
oaire.citationEndPage | 53 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 177 | por |
dc.identifier.eissn | 1532-2971 | - |
dc.identifier.doi | 10.1016/j.tvjl.2007.05.024 | por |
dc.identifier.pmid | 17631398 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | The Veterinary Journal | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gama-2008-Expression-of-e-cadherin-p-cadherin.pdf | 928,58 kB | Adobe PDF | Ver/Abrir |