Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61600

TitleExpression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
Author(s)Gama, Adelina
Paredes, Joana
Gärtner, Fátima
Alves, Anabela
Schmitt, Fernando
KeywordsAnimals
Biomarkers, Tumor
Cadherins
Disease-Free Survival
Dog Diseases
Dogs
Female
Immunohistochemistry
Lymph Nodes
Lymphatic Metastasis
Mammary Neoplasms, Animal
Neoplasm Invasiveness
Prognosis
Survival Analysis
Beta Catenin
Gene Expression Regulation, Neoplastic
Canine
Mammary tumours
E-cadherin
P-cadherin
β-Catenin
Issue dateJul-2008
PublisherElsevier
JournalThe Veterinary Journal
Abstract(s)Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.
TypeArticle
URIhttp://hdl.handle.net/1822/61600
DOI10.1016/j.tvjl.2007.05.024
ISSN1090-0233
e-ISSN1532-2971
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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