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|Title:||Opinion on moderate/low cancer genetic risk markers in medical practice including comment on the article Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology by Lubinski et al., Breast Cancer Res Treat 2008 Apr 15|
Schmitt, Fernando C.
|Journal:||Hereditary Cancer in Clinical Practice|
|Abstract(s):||[Excerpt] Breast cancer is a heterogeneous disease characterized by a widely variable morphological appearance, many risk factors and distinct gene expression profiles [1, 2]. Common genetic alterations (e.g. polymorphisms), with possible effects on protein function and/or expression, within genes involved in essential cellular pathways, such as carcinogen metabolism, DNA repair, cell cycle control and cell proliferation, can predispose individuals to various tumours, including breast cancer [3-7]. [...]|
|Appears in Collections:||ICVS - Artigos em Revistas Internacionais com Referee|
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