Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61483
Título: | Targeting metabolic reprogramming in acute myeloid leukemia |
Autor(es): | Castro, Isabel Marques, Maria Belém Sousa Sampaio Ludovico, Paula |
Palavras-chave: | metabolism acute myeloid leukemia preclinical and clinical trials on metabolic targets |
Data: | 24-Ago-2019 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Cells |
Citação: | Castro, I.; Sampaio-Marques, B.; Ludovico, P. Targeting Metabolic Reprogramming in Acute Myeloid Leukemia. Cells 2019, 8, 967. |
Resumo(s): | The cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further promote tumor growth and progression. These metabolic alterations have been exploited in different cancers, including acute myeloid leukemia, as novel therapeutic strategies both in preclinical models and clinical trials. Here, we review the complexity of acute myeloid leukemia (AML) metabolism and discuss how therapies targeting different aspects of cellular metabolism have demonstrated efficacy and how they provide a therapeutic window that should be explored to target the metabolic requirements of AML cells. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61483 |
DOI: | 10.3390/cells8090967 |
ISSN: | 2073-4409 |
Versão da editora: | https://www.mdpi.com/2073-4409/8/9/967 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
cells-08-00967.pdf | 756,1 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons