Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61457

TitleT-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population
Author(s)Carvalho, Agostinho
Santos, M.
Maciel, P.
Rodrigues, Fernando José dos Santos
KeywordsAdult
Age of Onset
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Multiple Sclerosis
Portugal
Promoter Regions, Genetic
Severity of Illness Index
Toll-Like Receptor 9
Polymorphism, Genetic
Disease
Inflammation
Innate immunity
Susceptibility
toll-like receptor
Issue dateMay-2008
PublisherSAGE Publications
JournalMultiple Sclerosis
Abstract(s)Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients.
TypeArticle
URIhttp://hdl.handle.net/1822/61457
DOI10.1177/1352458507084594
ISSN1352-4585
e-ISSN1477-0970
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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