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|Title:||Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis|
Pasqualotto, A. C.
Denning, D. W.
Rodrigues, Fernando José dos Santos
Aspergillosis, Allergic Bronchopulmonary
Lung Diseases, Fungal
Polymorphism, Single Nucleotide
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 9
|Publisher:||Oxford University Press|
|Journal:||Journal of Infectious Diseases|
|Abstract(s):||Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.|
|Appears in Collections:||ICVS - Artigos em revistas internacionais / Papers in international journals|