Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61456

TitlePolymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
Author(s)Carvalho, Agostinho
Pasqualotto, A. C.
Pitzurra, L.
Romani, L
Denning, D. W.
Rodrigues, Fernando José dos Santos
KeywordsAged
Aspergillosis
Aspergillosis, Allergic Bronchopulmonary
Aspergillus fumigatus
Case-Control Studies
Cohort Studies
Female
Humans
Lung Diseases, Fungal
Male
Middle Aged
Polymorphism, Single Nucleotide
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 9
Issue date15-Feb-2008
PublisherOxford University Press
JournalJournal of Infectious Diseases
Abstract(s)Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
TypeArticle
URIhttp://hdl.handle.net/1822/61456
DOI10.1086/526500
ISSN0022-1899
e-ISSN1537-6613
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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