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TitlePolymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
Author(s)Carvalho, Agostinho
Pasqualotto, A. C.
Pitzurra, L.
Romani, L
Denning, D. W.
Rodrigues, Fernando José dos Santos
Aspergillosis, Allergic Bronchopulmonary
Aspergillus fumigatus
Case-Control Studies
Cohort Studies
Lung Diseases, Fungal
Middle Aged
Polymorphism, Single Nucleotide
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 9
Issue date15-Feb-2008
PublisherOxford University Press
JournalJournal of Infectious Diseases
Abstract(s)Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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