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https://hdl.handle.net/1822/61454
Título: | N-terminal-pro-B type natriuretic peptide as a useful tool to evaluate pulmonary hypertension and cardiac function in CDH infants |
Autor(es): | Baptista, Maria João Ribeiro Leite Rocha, Gustavo Clemente, Fátima Azevedo, Luís F. Tibboel, Dick Leite-Moreira, Adelino F. Guimarães, Hercília Areias, José C. Correia-Pinto, Jorge |
Palavras-chave: | Blood Pressure Case-Control Studies Echocardiography Female Heart Hernia, Diaphragmatic Humans Hypertension, Pulmonary Infant, Newborn Male Natriuretic Peptide, Brain Peptide Fragments Prognosis Prospective Studies Severity of Illness Index Hernias, Diaphragmatic, Congenital N-terminal-pro-B type natriuretic peptide Cardiac function Diastole congenital diaphragmatic hernia pulmonary hypertension |
Data: | 2008 |
Editora: | Karger Publishers |
Revista: | Neonatology |
Resumo(s): | Objective: In congenital diaphragmatic hernia (CDH) the severity of pulmonary hypertension (PH) is considered, by several authors, determinant of clinical outcome. Plasmatic N-terminal-pro-B type natriuretic peptide (NT-proBNP) might be useful in diagnosis and management of PH in newborns, although its interest in CDH infants remains to be defined. Early NT-proBNP levels were assessed in CDH infants and correlated with cardiovascular echocardiographic parameters. Patients and Methods: 28 newborns, CDH and age-matched controls were enrolled in a prospective study. Clinical condition, NT-proBNP plasmatic levels, echo parameters of PH and biventricular function were assessed at 24 h after delivery as well as survival outcome. Results: Estimated mean pulmonary pressure and NT-proBNP were significantly higher in CDH than control infants. NT-proBNP significantly correlated with estimated pulmonary artery pressure, right ventricular Tei index, and tricuspid E/A ratio. Additionally, we found that CDH infants with NT-proBNP >11,500 pg/ml experienced a worse prognosis. Conclusions: We demonstrated that PH is associated with NT-proBNP elevation and diastolic impairment in CDH infants. Early elevations in NT-proBNP levels seem to alert for a subset of CDH infants with worse prognosis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61454 |
DOI: | 10.1159/000112641 |
ISSN: | 1661-7800 |
e-ISSN: | 1661-7819 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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baptista2007.pdf Acesso restrito! | 199,9 kB | Adobe PDF | Ver/Abrir |