Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61319

TitleFucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo
Author(s)Oliveira, Ana Catarina Freitas Salazar
Granja, Sara Costa
Neves, N. M.
Reis, R. L.
Baltazar, Fátima
Silva, Tiago José Quinteiros Lopes Henriques
Martins, Albino
KeywordsAngiogenesis
Fucoidan
Tumor
Anticancer
Issue date2019
PublisherElsevier
JournalCarbohydrate Polymers
CitationOliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., Martins A. Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo, Carbohydrate Polymers, Vol. 223, doi:10.1016/j.carbpol.2019.115034, 2019
Abstract(s)Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent.
TypeArticle
URIhttp://hdl.handle.net/1822/61319
DOI10.1016/j.carbpol.2019.115034
ISSN0144-8617
e-ISSN1879-1344
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0144861719307015
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
19910-1-s2.0-S0144861719307015-main.pdf2,59 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID