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TitleTherapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
Author(s)Souto, Eliana
Dias-Ferreira, João
Craveiro, Sara A.
Severino, Patrícia
Sanchez-Lopez, Elena
Garcia, Maria L.
Silva, Amélia M.
Souto, Selma B.
Mahant, Sheefali
KeywordsNeglected diseases
drug delivery systems
antiprotozoal agents
Chagass disease
Chagas's disease
Issue dateAug-2019
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
CitationSouto, Eliana; Dias-Ferreira, João; Craveiro, Sara A.; Severino, Patrícia; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Souto, Selma B.; Mahant, Sheefali, Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems. Pathogens, 8(3), 119, 2019
Abstract(s)The incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagass disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health care systems. Both Leishmaniasis and Chagass disease are caused by different protozoa and develop diverse symptoms, which depend on the specific species infecting man. Currently available drugs to treat these disorders have limited therapeutic outcomes, frequently due to microorganisms drug resistance. In recent years, significant efforts have been made towards the development of innovative drug delivery systems aiming to improve bioavailability and pharmacokinetic profiles of classical drug therapy. This paper discusses the key facts of Leishmaniasis and Chagass disease, the currently available pharmacological therapies and the new drug delivery systems for conventional drugs.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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