Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/61051

TitleLight-triggered release of photocaged therapeutics: where are we now?
Author(s)Silva, Joana Maria Marques
Silva, Eduardo
Reis, R. L.
KeywordsDrug delivery
Photochemistry
Stimuli-responsiveness
Targeting
Issue date2019
PublisherElsevier
JournalJournal of Controlled Release
CitationSilva J. M., Silva E., Reis R. L. Light-triggered release of photocaged therapeutics-Where are we now?, Journal of Controlled Release, Vol. 298, pp. 154-176, doi:10.1016/j.jconrel.2019.02.006, 2019
Abstract(s)The current available therapeutics face several challenges such as the development of ideal drug delivery systems towards the goal of personalized treatments for patients benefit. The application of light as an exogenous activation mechanism has shown promising outcomes, owning to the spatiotemporal confinement of the treatment in the vicinity of the diseased tissue, which offers many intriguing possibilities. Engineering therapeutics with light responsive moieties have been explored to enhance the bioavailability, and drug efficacy either in vitro or in vivo. The tailor-made character turns the so-called photocaged compounds highly desirable to reduce the side effects of drugs and, therefore, have received wide research attention. Herein, we seek to highlight the potential of photocaged compounds to obtain a clear understanding of the mechanisms behind its use in therapeutic delivery. A deep overview on the progress achieved in the design, fabrication as well as current and possible future applications in therapeutics of photocaged compounds is provided, so that novel formulations for biomedical field can be designed.
TypeArticle
URIhttp://hdl.handle.net/1822/61051
ISBN0168-3659
DOI10.1016/j.jconrel.2019.02.006
ISSN0168-3659
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0168365919300793
Peer-Reviewedno
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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