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TitleUveal melanoma: physiopathology and new in situ-specific therapies
Author(s)Souto, Eliana
Zielinska, A.
Luis, M.
Carbone, C.
Martins-Gomes, C.
Souto, S. B.
Silva, A. M.
KeywordsUveal melanoma
Transpupillary thermal therapy
Photodynamic therapy
Liver metastases
Liver-directed therapies
Issue dateJul-2019
PublisherSpringer Nature
JournalCancer Chemotherapy and Pharmacology
CitationSouto, Eliana; Zielinska, A.; Luis, M.; Carbone, C.; Martins-Gomes, C.; Souto, S. B.; Silva, A. M., Uveal melanoma: physiopathology and new in situ-specific therapies. Cancer Chemotherapy and Pharmacology, 84(1), 15-32, 2019
Abstract(s)Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e.g., GNAQ/GNA11; BAP1), which are considered promising targets for molecular therapy. Primary treatment of uveal melanoma includes radiotherapy (brachytherapy and charged-particle therapy), phototherapy (photocoagulation, transpupillary thermal therapy, and photodynamic therapy) and surgery (local resection, enucleation and exenteration). Approximately half of patients with uveal melanoma will, however, develop metastasis, especially in the liver. The treatment of metastatic uveal melanoma includes systemic chemotherapy, immunotherapy and molecular targeted therapy. Liver-directed therapies, such as resection, chemoembolization, immunoembolization, radioembolization, isolated hepatic perfusion and percutaneous hepatic perfusion, are also available to treat metastatic uveal melanoma. Several clinical trials are being developed to study new therapeutic options to treat uveal melanoma, mainly for those with identified liver metastases. The present work discusses the physiopathology and new in situ-specific therapies for the treatment of uveal melanoma.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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