Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/60771

TitleDevelopment of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes
Author(s)Silva, Joana Maria Marques
Akkache, S.
Araújo, Ana C.
Masmoudi, Y.
Reis, R. L.
Badens, E.
Duarte, Ana Rita C.
KeywordsAntibacterial
D-RESS
Eutectic mixture
Fatty acids
PGSS
Thermosensitive devices
Issue dateJun-2019
PublisherElsevier
JournalMaterials Science & Engineering: C
CitationSilva J. M., Akkache S., Araujo A., Masmoudi Y., Reis R. L., Badens E., Duarte A. R. C. Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes, Materials Science & Engineering C, Vol. 99, pp. 599-610, doi:10.1016/j.msec.2019.02.012, 2019
Abstract(s)In order to limit bacterial infections during wound treatment, it is interesting to consider the concept of loadingmedical devices with antibacterial agents. With this in mind, an innovative system with thermosensitive prop-erties was produced: loading a commercially available gauze with a fatty acid eutectic blend based on lauric acid(LA) and myristic acid (MA). This eutectic blend presents a melting point near physiological temperature, whichtogether with its antibacterial properties make an appealing alternative in biomedical applications. At roomtemperature, the properties and the efficacy of the eutectic blend loaded onto gauzes are preserved, whereas atphysiological temperature the eutectic blend undergoes a phase change that facilitates its diffusion from thegauze. The loading of the eutectic blend onto gauzes was performed using two different supercriticalfluidtechnologies, namely, particle from gas saturated solutions (PGSS) and a derived version of rapid expansion ofsupercritical solution (D-RESS). The PGSS led to a heterogeneous dispersion of the eutectic blend in the gauze,whereas the D-RESS process led to the formation of a homogeneous dispersion along the surface of the gauze.Additionally, with D-RESS no phase separation of the eutectic blend occurred and the cytotoxicity was greatlyimproved compared with PGSS without compromising the antibacterial properties of the fatty acid eutecticblend. Hence, the present study highlights the potential use of theflexible D-RESS process to load the fatty acideutectic blend with antibacterial properties onto medical devices in a controllable way. Overall, the effectsproduced by the loaded gauzes suggest the enormous potential of the developed technology in health-relatedareas.
TypeArticle
URIhttp://hdl.handle.net/1822/60771
DOI10.1016/j.msec.2019.02.012
ISSN0928-4931
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0928493118321295
Peer-Reviewedno
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


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