Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/60765

TitleSolid magnetoliposomes entrapping new potential antitumor drugs for applications in cancer therapy
Author(s)Ferreira, João M. C.
Rodrigues, Juliana M.
Rodrigues, Ana Rita Oliveira
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
Queiroz, Maria João R. P.
KeywordsMagnetic nanoparticles
Magnetoliposomes
Drug delivery
Antitumor drugs
Cancer therapy
Issue date2019
Abstract(s)In this work, new solid magnetoliposomes (nanoparticle aggregates covered by a lipid/surfactant bilayer), containing manganese ferrite nanoparticles, have been developed. For that, a first layer of octadecylamine (ODA) was covalently linked to the nanoparticles surface and then covered by a layer of the phospholipid DPPC (second layer). These nanosystems exhibit diameters below 150 nm and the capability to interact with models of biomembranes (Giant Unilamellar Vesicles, GUVs) by fusion. The solid magnetoliposomes were successfully tested as nanocarriers for new fluorescent promising antitumor compounds.
TypeAbstract
URIhttp://hdl.handle.net/1822/60765
Peer-Reviewedyes
AccessOpen access
Appears in Collections:PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)

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