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TitleNew nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: Synthesis and structure–activity relationship
Author(s)Bettencourt, Ana Paula
Castro, Marián
Silva, João
Fernandes, Francisco
Coutinho, O. P.
Sousa, Maria João
Proença, M. Fernanda R. P.
Areias, Filipe
phenolic compounds
antifungal activity
antioxidant capacity
structure-activity relationship
Issue date3-Oct-2018
PublisherMultidisciplinary Digital Publishing Institute
Abstract(s)A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes <b>3</b> was synthesized and cyclized to 2-aryl-4,5-dicyano-1<i>H</i>-imidazoles <b>4</b> upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, <i>Saccharomyces cerevisiae</i> and <i>Candida albicans</i>. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugs.
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)
DBio - Artigos/Papers

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