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|Title:||New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: Synthesis and structure–activity relationship|
|Author(s):||Bettencourt, Ana Paula|
Coutinho, O. P.
Sousa, Maria João
Proença, M. Fernanda R. P.
|Publisher:||Multidisciplinary Digital Publishing Institute|
|Abstract(s):||A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes <b>3</b> was synthesized and cyclized to 2-aryl-4,5-dicyano-1<i>H</i>-imidazoles <b>4</b> upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, <i>Saccharomyces cerevisiae</i> and <i>Candida albicans</i>. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugs.|
|Appears in Collections:||CDQuim - Artigos (Papers)|
DBio - Artigos/Papers
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