Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/6062

TitleEffect of farnesol on Candida dubliniensis morphogenesis
Author(s)Henriques, Mariana
Martins, Margarida Isabel Barros Coelho
Azeredo, Joana
Oliveira, Rosário
KeywordsCandida albicans
Candida dubliniensis
Farnesol
Hyphae
Morphology alteration
Pseudohyphae
Issue dateFeb-2007
PublisherBlackwell Publishing
JournalLetters in Applied Microbiology
Citation"Letters in applied microbiology". ISSN 0266-8254. 44:2 (Febr. 2007) 199-205.
Abstract(s)Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. morphogenesis. Methods and Results: Two different strains of C. dubliniensis and one of C. albicans were grown both in RPMI 1640 and in serum in the presence of absence of farnesol. At 150 μmol l -1 farnesol the growth rate of both Candida species was not affected. On the contrary, farnesol inhibited hyphae and pseudohyphae formation in C. dubliniensis. Conclusion: Farnesol seems to mediate cell morphology in both Candida species. Significance and Impact of the Study: The effect of farnesol on C. dubliniensis morphology was not reported previously.
TypeArticle
URIhttp://hdl.handle.net/1822/6062
DOI10.1111/j.1472-765X.2006.02044.x
ISSN0266-8254
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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