Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60338
Título: | The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis |
Autor(es): | Cazzanelli, Giulia Pereira, Flávia Alves, Sara Francisco, Rita Azevedo, Luísa Dias Carvalho, Patrícia Almeida, Ana Côrte-Real, Manuela Oliveira, Maria José Lucas, Cândida Sousa, Maria João Preto, Ana |
Palavras-chave: | RAS proteins S. cerevisiae model homologues colorectal cancer autophagy KRAS |
Data: | 19-Fev-2018 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Cells |
Resumo(s): | The exploitation of the yeast <i>Saccharomyces cerevisiae</i> as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries. When comparing yeast and human proteins, it is clear that both amino acid sequences and protein functions are often very well conserved. One example of the high degree of conservation between human and yeast proteins is highlighted by the members of the RAS family. Indeed, the study of the signaling pathways regulated by RAS in yeast cells led to the discovery of properties that were often found interchangeable with RAS proto-oncogenes in human pathways, and vice versa. In this work, we performed an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, we emphasized the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/60338 |
DOI: | 10.3390/cells7020014 |
ISSN: | 2073-4409 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cells-07-00014-v2.pdf | 5,44 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons