Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/60338

TitleThe Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis
Author(s)Cazzanelli, Giulia
Pereira, Flávia
Alves, Sara
Francisco, Rita
Azevedo, Luísa
Dias Carvalho, Patrícia
Almeida, Ana
Côrte-Real, Manuela
Oliveira, Maria José
Lucas, Cândida
Sousa, Maria João
Preto, Ana
KeywordsRAS proteins
S. cerevisiae
model
homologues
colorectal cancer
autophagy
KRAS
Issue date19-Feb-2018
PublisherMultidisciplinary Digital Publishing Institute
JournalCells
Abstract(s)The exploitation of the yeast <i>Saccharomyces cerevisiae</i> as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries. When comparing yeast and human proteins, it is clear that both amino acid sequences and protein functions are often very well conserved. One example of the high degree of conservation between human and yeast proteins is highlighted by the members of the RAS family. Indeed, the study of the signaling pathways regulated by RAS in yeast cells led to the discovery of properties that were often found interchangeable with RAS proto-oncogenes in human pathways, and vice versa. In this work, we performed an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, we emphasized the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.
TypeArticle
URIhttp://hdl.handle.net/1822/60338
DOI10.3390/cells7020014
ISSN2073-4409
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DBio - Artigos/Papers

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