Please use this identifier to cite or link to this item:

TitleBioactive properties of Tabebuia impetiginosa-based phytopreparations and phytoformulations: a comparison between extracts and dietary supplements
Author(s)Pires, Tânia C. S. P.
Dias, Maria Inês
Calhelha, Ricardo C.
Carvalho, Ana Maria
Queiroz, Maria João R. P.
Barros, Lillian
Ferreira, Isabel C. F. R.
KeywordsTabebuia impetiginosa
methanolic extract
dietary supplements
chemical composition
Methanolic extract/infusion/dietary supplements
Issue date21-Dec-2015
PublisherMultidisciplinary Digital Publishing Institute
Abstract(s)<i>Tabebuia impetiginosa</i> (Mart. ex DC.) Standl. has been used in traditional medicine for many centuries, being nowadays marketed as dried plant material (inner bark) for infusions, pills, and syrups. The main objective of the present work was to validate its popular use through the bioactivity evaluation of the inner bark (methanolic extract and infusion) and of two different formulations (pills and syrup) also based on the same plant-material. The antioxidant activity was evaluated by in vitro assays testing free radical scavenging activity, reducing power and inhibition of lipid peroxidation in brain homogenates. The cytotoxicity was determined in four human tumor cell lines (MCF-7, NCI-H460, HeLa and HepG2, and also in non-tumor cells (porcine liver primary cells, PLP2)). Furthermore, the sample was chemically characterized regarding free sugars, organic acids, fatty acids, and tocopherols. Syrup and methanolic extract showed the highest antioxidant activity, related to their highest amount of phenolics and flavonoids. Methanolic extract was the only sample showing cytotoxic effects on the tested human tumor cell lines, but none of the samples showed toxicity in PLP2. Glucose and oxalic acid were, respectively, the most abundant sugar and organic acid in the sample. Unsaturated predominated over the saturated fatty acids, due to oleic, linoleic, and linolenic acids expression. α- and γ-Tocopherols were also identified and quantified. Overall, <i>T. impetiginosa</i> might be used in different phytoformulations, taking advantage of its interesting bioactive properties and chemical composition.
AccessOpen access
Appears in Collections:BUM - MDPI
CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
molecules-20-19885.pdf206,59 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID