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TitleRemote activation of activin a type ii receptor via magnetic nanoparticles for tendon regeneration strategies
Author(s)Gonçalves, A I
Rotherham, M.
Markides, H.
Rodrigues, Márcia T.
Reis, R. L.
Gomes, Manuela E.
Haj, A. E.
KeywordsActivin receptor type IIA
TGF-β/Smad2/3 signaling pathway
Issue dateApr-2018
PublisherThe British Editorial Society of Bone & Joint Surgery
CitationGonçalves A. I., Rotherham M., Markides H., Rodrigues M. T., Reis R. L., Gomes M. E., Haj A. E. Remote activation of activin a type ii receptor via magnetic nanoparticles for tendon regeneration strategies, Orthopaedic Proceedings, Vol. 100-B, Issue S4, doi:10.1302/1358-992X.2018.4.072, 2018
Abstract(s)Tendon injuries are a worldwide problem affecting several age groups and stem cell based therapies hold potential for tendon strategies guiding tendon regeneration. Tendons rely on mechano-sensing mechanisms that regulate homeostasis and influence regeneration. The mechanosensitive receptors available in cell membranes sense the external stimuli and initiate mechanotransduction processes. Activins are members of the TGF-β superfamily which participate in several tendon biological processes. It is envisioned that the activation of the activin receptor, trigger downstream Smad2/3 pathway thus regulating the transcription of tenogenic genes driving stem cell differentiation.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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