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TitleDesign and performance assessment of a solid-state microcooler for thermal neuromodulation
Author(s)Fernandes, José
Vendramini, Estelle
Miranda, Ana M.
Silva, Cristiana
Dinis, Hugo
Coizet, Veronique
David, Olivier
Mendes, P. M.
Keywordssolid-state cooling
microsystem integration
thermal simulation
thermal neuromodulation
microdevice packaging
biomedical microdevice
Issue date27-Jan-2018
PublisherMultidisciplinary Digital Publishing Institute
Abstract(s)It is well known that neural activity can be modulated using a cooling device. The applications of this technique range from the treatment of medication-resistant cerebral diseases to brain functional mapping. Despite the potential benefits of such technique, its use has been limited due to the lack of suitable thermal modulators. This paper presents the design and validation of a solid-state cooler that was able to modulate the neural activity of rodents without the use of large and unpractical water pipes. A miniaturized thermal control solution based exclusively on solid-state devices was designed, occupying only 5 mm × 5 mm × 3 mm, and featuring the potential for wireless power and communications. The cold side of the device was cooled to 26 °C, while the hot side was kept below 43 °C. This range of temperatures is compatible with brain cooling and efficient enough for achieving some control of neural activity.
AccessOpen access
Appears in Collections:BUM - MDPI

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