Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/59549

TitleThe therapeutic potential of apigenin
Author(s)Salehi, Bahare
Venditti, Alessandro
Sharifi-Rad, Mehdi
Kregiel, Dorota
Sharifi-Rad, Javad
Durazzo, Alessandra
Lucarini, Massimo
Santini, Antonello
Souto, Eliana
Novellino, Ettore
Antolak, Hubert
Azzini, Elena
Setzer, William N.
Martins, Natália
Keywordsapigenin
flavonoids
chronic diseases
diabetes
cancer
Issue date15-Mar-2019
PublisherMDPI
JournalInternational Journal of Molecular Sciences
CitationSalehi, Bahare; Venditti, Alessandro; Sharifi-Rad, Mehdi; Kregiel, Dorota; Sharifi-Rad, Javad; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Souto, Eliana; Novellino, Ettore; Antolak, Hubert; Azzini, Elena; Setzer, William N.; Martins, Natália, The therapeutic potential of apigenin. International Journal of Molecular Sciences, 20(6), 1305, 2019
Abstract(s)Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
TypeArticle
URIhttp://hdl.handle.net/1822/59549
ISBN1424-6783
DOI10.3390/ijms20061305
ISSN1422-0067
e-ISSN1661-6596
Publisher versionhttp://www.mdpi.com/journal/ijms
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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