Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/59525

TitlePhage therapy: going temperate?
Author(s)Monteiro, Rodrigo
Pires, Diana Priscila Penso
Costa, Ana Rita Martins
Azeredo, Joana
KeywordsPhage therapy
Temperate phages
Synthetic biology
Antibiotic resistance
CRISPR-Cas
Issue date2018
PublisherElsevier
JournalTrends in Microbiology
CitationMonteiro, Rodrigo; Pires, Diana P.; Costa, Ana Rita; Azeredo, Joana, Phage Therapy: Going Temperate?. Trends in Microbiology, 27(4), 368-378, 2018.
Abstract(s)Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.
Typereview
URIhttp://hdl.handle.net/1822/59525
DOI10.1016/j.tim.2018.10.008
ISSN0966-842X
Publisher versionhttp://www.cell.com/trends/microbiology/home
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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