Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/59525
Título: | Phage therapy: going temperate? |
Autor(es): | Monteiro, Rodrigo Pires, Diana Priscila Penso Costa, Ana Rita Martins Azeredo, Joana |
Palavras-chave: | Phage therapy Temperate phages Synthetic biology Antibiotic resistance CRISPR-Cas |
Data: | 2019 |
Editora: | Elsevier |
Revista: | Trends in Microbiology |
Citação: | Monteiro, Rodrigo; Pires, Diana P.; Costa, Ana Rita; Azeredo, Joana, Phage Therapy: Going Temperate?. Trends in Microbiology, 27(4), 368-378, 2018. |
Resumo(s): | Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/59525 |
DOI: | 10.1016/j.tim.2018.10.008 |
ISSN: | 0966-842X |
Versão da editora: | http://www.cell.com/trends/microbiology/home |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49200_1.pdf | 2,08 MB | Adobe PDF | Ver/Abrir |