Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/5947
Título: | Medullary control of nociceptive transmission: reciprocal dual communication with the spinal cord |
Autor(es): | Almeida, Armando Almeida, Hugo Leite Tavares, Isaura |
Palavras-chave: | Pain modulation Pain facilitation Pain inhibition Antinociception Pronociception Brainstem DRt VLMLat LRt Brain-spinal cord circuits Spinal cord Nociception |
Data: | 2006 |
Editora: | Elsevier |
Revista: | Drug Discovery Today: Disease Mechanisms |
Citação: | "Drug discovery today : disease mechanics". ISSN 1740-6765. 3:3 (2006) 305-312. |
Resumo(s): | Control of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and disruption of a balanced brain-spinal communication. Targets for impeding pain chronification are being developed using the manipulation of the cross talk between brain and dorsal horn, at both sites of the loop. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/5947 |
DOI: | 10.1016/j.ddmec.2006.09.001 |
ISSN: | 1740-6765 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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DDT Dis Mechan 3 305.pdf | 3,37 MB | Adobe PDF | Ver/Abrir |