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|Title:||Degradable particulate composite reinforced with nanofibre meshes for biomedical applications|
|Author(s):||Pinho, E. D.|
Araújo, J .V.
Reis, R. L.
Neves, N. M.
|Publisher:||Mary Ann Liebert Inc.|
|Journal:||Tissue Engineering. Part A|
|Abstract(s):||[Excerpt] In the biomaterials field, nanofibre based structures and its composites are promising materials to produce scaffolds mimicking the architecture of the extracellular matrix (ECM). The main purpose of this work was to develop a novel composite structure which combines polymeric microfibres reinforced by nanofibres. This combination was obtained by melting extrusion of a composite with a natural polymer, Chitosan particles, and a biodegradable polymer, poly(butylene succinate) (50:50 wt), reinforced with chitosan nanofibre meshes (0.05% wt). The chitosan meshes were produced by electrospinning. The nanofibre reinforced microfibres were analysed by SEM demonstrated a considerable alignment of the nanofibres along the longitudinal axis of the microfibres. [...]|
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