Carrageenan-based hydrogels as potential systems for the delivery of PDGF in bone tissue regeneration strategies

Abstract

[Excerpt] One of the major drawbacks found in most bone tissue engineering (TE) approaches developed so far consists in the lack of strategies to promote vascularization. Some studies have addressed different issues that may enhance vascularization in TE constructs, most of them involving the use of growth factors that are involved in the restitution of the vascularity in a damaged zone. The use of sustained delivery systems might also play an important role in the reestablishment of angiogenesis. [...]