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TitleEffect of pH on the control release of microencapsulated dye in lecithin liposomes. II
Author(s)Baptista, A. L. F.
Coutinho, P. J. G.
Real Oliveira, M. Elisabete C.D.
Gomes, J. I. N. Rocha
KeywordsDrug Compounding
Fluorescent Dyes
Hydrogen-Ion Concentration
Spectrometry, Fluorescence
Issue dateMay-2003
PublisherMarcel Dekker Inc.
JournalJournal of Liposome Research
Abstract(s)The objective of our work has been the microencapsulation of dyes with lecithin from soybean, with the formation of liposomes, as a substitute for synthetic auxiliaries so as to improve the quality of the effluent. Current scenarios promote the disintegration and leakage of the liposomes, such as, changes in temperature, pH, and the use of surfactants. Since dyeing process is a mix of all these parameters, we pretended to study each one separately. Changes in pH at constant temperature induce a release of dye similar with changes in temperature. In acid conditions, we found a very fast initial dye release which doesn't occur in basic conditions. Using carboxyfluorescein, as a pH fluorescence probe, we concluded that the liposome membrane doesn't protect the liposome interior from changes on the external pH.
AccessRestricted access (UMinho)
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)

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