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TitleBioactive Hydrogel Marbles
Author(s)Leite, Álvaro J.
Oliveira, Nuno M.
Song, W.
Mano, J. F.
KeywordsBioactive nanoparticles
Issue dateOct-2018
PublisherNature Research
JournalScientific Reports
CitationLeite A. J., Oliveira N. M., Song W., Mano J. F. Bioactive Hydrogel Marbles, Scientific Reports, Vol. 8, Issue 15215, pp. 1-11, doi:10.1038/s41598-018-33192-6, 2018
Abstract(s)Liquid marbles represented a signifcant advance in the manipulation of fuids as they used particle flms to confne liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifcally, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efcient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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