Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration

doi:10.1007/5584_2018_258

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/58811

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Campo DC	Valor	Idioma
dc.contributor.author	Vinhas, A.	por
dc.contributor.author	Rodrigues, Márcia T.	por
dc.contributor.author	Gomes, Manuela E.	por
dc.date.accessioned	2019-01-31T10:32:07Z	-
dc.date.issued	2018-08	-
dc.date.submitted	2019-01	-
dc.identifier.citation	Vinhas A., Rodrigues M. T., Gomes M. E. Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration, Adv Exp Med Biol – Cell Biology and Translational Medicine, Vol. 2, pp. 37-46, doi:10.1007/5584_2018_258., 2018	por
dc.identifier.isbn	978-3-030-04169-4	por
dc.identifier.issn	2522-090X	-
dc.identifier.uri	https://hdl.handle.net/1822/58811	-
dc.description.abstract	Tendon injuries are frequent and are responsible for substantial morbidity both in sports and in the workplace. Despite the endogenous mechanisms of tendon repair and regeneration, tendon healing upon injury is slow and often insufficient to restore complete biomechanics functionality. Inflammation has a pivotal role in tendon healing and failed healing responses contribute to the progression of tendinopathies. However, the molecular and cellular mechanisms involved are poorly understood requiring further insights. During inflammation, bioactive molecules such as cytokines secreted locally at the injury site, influence resident stem cells that contribute as modulatory agents over the niche towards homeostasis, holding great promise as therapeutic agents for tendon pathological conditions associated to unresolved inflammation and failed healing. This review overviews the role of cytokines and resident cells, focusing on the participation of tendon stem cell population in inflammation and tendon healing upon injury and their potential action in resolution of pathological conditions	por
dc.description.sponsorship	Fundação para a Ciência e Tecnologia (FCT) for the doctoral grant PD/BD/128089/2016, the project NORTE-01-0145-FEDER-000021 supported by Norte Portugal Regional Operational Programme (NORTE 2020) and HORIZON 2020 under the TEAMING GRANT agreement No 739572 – The Discoveries CTR	por
dc.language.iso	eng	por
dc.publisher	Springer Nature	por
dc.rights	restrictedAccess	por
dc.subject	Cytokines	por
dc.subject	Healing	por
dc.subject	Inflammation	por
dc.subject	Mechanical stimulation	por
dc.subject	Pathology	por
dc.subject	Repair	por
dc.subject	Tendon	por
dc.subject	Tenocytes	por
dc.title	Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration	por
dc.type	bookPart	por
dc.peerreviewed	yes	-
dc.relation.publisherversion	https://link.springer.com/chapter/10.1007/5584_2018_258	por
dc.comments	http://3bs.uminho.pt/node/19700	por
oaire.citationStartPage	37	por
oaire.citationEndPage	46	por
oaire.citationVolume	2	-
dc.date.updated	2019-01-30T10:10:49Z	-
dc.identifier.doi	10.1007/5584_2018_258	por
dc.identifier.eisbn	978-3-030-04170-0	por
dc.identifier.pmid	30088259	por
dc.subject.fos	Ciências Médicas::Biotecnologia Médica	por
dc.description.publicationversion	info:eu-repo/semantics/publishedVersion	por
dc.subject.wos	Science & Technology	por
sdum.journal	Advances in Experimental Medicine and Biology	por
sdum.conferencePublication	CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 2: APPROACHES FOR DIVERSE DISEASES AND CONDITIONS	por
sdum.bookTitle	Cell Biology and Translational Medicine, Volume 2. Approaches for Diverse Diseases and Conditions	por
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