Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58780

TitleMetabolic crosstalk between host and parasitic pathogens
Author(s)Moreira, Diana Raquel Bento
Estaquier, Jérôme
Silva, Anabela Cordeiro da
Silvestre, Ricardo Jorge Leal
KeywordsHost metabolic landscape
Host metabolic pathways
Host–parasite interaction
Nutrient sensing pathways
Scavenging of nutrients
Issue date2018
JournalExperientia Supplementum
Abstract(s)A complex network that embraces parasite-host intrinsic factors and the microenvironment regulated the interaction between a parasite and its host. Nutritional pressures exerted by both elements of this duet thus dictate this host-parasite niche. To survive and proliferate inside a host and a harsh nutritional environment, the parasites modulate different nutrient sensing pathways to subvert host metabolic pathways. Such mechanism is able to change the flux of distinct nutrients/metabolites diverting them to be used by the parasites. Apart from this nutritional strategy, the scavenging of nutrients, particularly host fatty acids, constitutes a critical mechanism to fulfil parasite nutritional requirements, ultimately defining the host metabolic landscape. The host metabolic alterations that result from host-parasite metabolic coupling can certainly be considered important targets to improve diagnosis and also for the development of future therapies. Metabolism is in fact considered a key element within this complex interaction, its modulation being crucial to dictate the final infection outcome.
TypeArticle
URIhttp://hdl.handle.net/1822/58780
DOI10.1007/978-3-319-74932-7_12
ISSN1664-431X
AccessRestricted access (Author)
Appears in Collections:ICVS - Livros e Capítulos de Livros

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