Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58778

TitleCellular metabolism at a glance
Author(s)Mesquita, Inês Morais
Rodrigues, Fernando José dos Santos
KeywordsBiosynthetic precursors
Energy
Homeostasis
Immunometabolism
Metabolic networks
Metabolic nodes
Regulation
Issue date2018
JournalExperientia Supplementum
Abstract(s)Metabolism is highly coordinated component of the cellular activity that involves sequential chemical transformations, within a so-called metabolic network. Through these coordinated actions, living organisms acquire energy and biosynthetic precursors to maintain cellular homeostasis and function. Metabolism relies on the breaking down of macromolecules to produce energy [catabolism] and/or intermediary metabolites that are then used to construct essential building blocks for macromolecule production [anabolism]. Overall, these metabolic processes are controlled by cellular energy status: when the energy released from catabolic processes exceeds the cellular demands the storage of metabolites in the form of lipids and glycogen takes place. These phenomena have been vastly associated with the genesis of metabolic disorders, such as obesity. In recent years, we have assisted to a rediscovery of metabolism through the identification of metabolic intermediaries that act as key players on differentiation, proliferation, and function of immune cells. This recent acknowledgement of the impact of metabolism in the overall immune response originated the ground-breaking field of immunometabolism. Here, we will provide a holistic view of metabolism highlighting the biochemical principles underlying its regulation.
TypeArticle
URIhttp://hdl.handle.net/1822/58778
DOI10.1007/978-3-319-74932-7_1
ISSN1664-431X
AccessRestricted access (Author)
Appears in Collections:ICVS - Livros e Capítulos de Livros

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