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TitleStrontium Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
Author(s)Leite, A. J.
Gonçalves, A I
Rodrigues, M. T.
Gomes, Manuela E.
Mano, J. F.
osteogenic differentiation
osteogenic commitment
Issue dateJun-2018
PublisherACS Publications
JournalACS Applied Materials and Interfaces
CitationLeite A. J., Gonçalves A. I., Rodrigues M. T., Gomes M. E., Mano J. F. Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment, ACS Appl. Mater. Interfaces, Vol. 10, Issue 27, pp. 23311–23320, doi:10.1021/acsami.8b06154, 2018
Abstract(s)The present work has explored bioactive glass nanoparticles (BGNPs) and developed strontium-doped nanoparticles (BGNPsSr), envisioning orthopedic strategies compatible with vascularization. The nanoparticles were synthesized by the solâ gel method, achieving a diameter of 55 nm for BGNPs and 75 nm for BGNPsSr, and the inclusion of strontium caused no structural alteration. The nanoparticles exhibited high cytocompatibility for human umbilical vein endothelial cells (HUVECs) and SaOS-2. Additionally, the incorporation of strontium emphasized the tubule networking behavior of HUVECs. Our results demonstrate that the nanoparticle dissolution products encouraged the osteogenic differentiation of human adipose stem cells as it favored the expression of key genes and proteins associated with osteogenic lineage. This effect was markedly enhanced for BGNPsSr, which could prompt stem cell osteogenic differentiation without the typical osteogenic inducers. This study not only supports the hypothesis that BGNPs might play a significant role in osteogenic commitment but also highlights that the designed BGNPsSr is a valuable tool for stem cell â tune-upâ in bone tissue engineering applications.
Description“Just Accepted” manuscript
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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