Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58737
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Mendes, B. B. | por |
dc.contributor.author | Gómez-Florit, M. | por |
dc.contributor.author | Babo, P. S. | por |
dc.contributor.author | Domingues, R. M. A. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2019-01-30T11:11:31Z | - |
dc.date.available | 2019-01-30T11:11:31Z | - |
dc.date.issued | 2018-04 | - |
dc.date.submitted | 2018-02 | - |
dc.identifier.citation | Mendes B. B., Gómez-Florit M., Babo P. S., Domingues R. M. A., Reis R. L., Gomes M. E. Blood derivatives awaken in regenerative medicine strategies to modulate wound healing, Advanced Drug Delivery Reviews, Vol. 129, pp. 376-393, doi:10.1016/j.addr.2017.12.018, 2018 | por |
dc.identifier.issn | 0169-409X | por |
dc.identifier.uri | https://hdl.handle.net/1822/58737 | - |
dc.description.abstract | Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies. | por |
dc.description.sponsorship | BBM acknowledges the financial support from FCT/MCTES (Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior) and the Fundo Social Europeu através do Programa Operacional do Capital Humano (FSE/POCH), PD/59/2013 for PD/BD/113807/2015. MGF acknowledges European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 706996 (PrinTendon). PB acknowledges RECOGNIZE and NORTE2020 (UTAP-ICDT/CTM-BIO/0023/2014). RMD acknowledges SFRH/BPD/112459/2015. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | PD/BD/113807/2015 | por |
dc.relation | 706996 | por |
dc.relation | SFRH/BPD/112459/2015 | por |
dc.rights | openAccess | por |
dc.subject | Biomaterials | eng |
dc.subject | Blood derivatives | eng |
dc.subject | Delivery | eng |
dc.subject | platelet | eng |
dc.subject | regenerative medicine | eng |
dc.subject | Tissue engineering | eng |
dc.subject | Wound healing | eng |
dc.title | Blood derivatives awaken in regenerative medicine strategies to modulate wound healing | eng |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S0169-409X(17)30321-6 | por |
dc.comments | http://3bs.uminho.pt/node/19321 | por |
oaire.citationStartPage | 376 | por |
oaire.citationEndPage | 393 | por |
oaire.citationVolume | 129 | por |
dc.date.updated | 2019-01-30T09:55:07Z | - |
dc.identifier.eissn | 1872-8294 | - |
dc.identifier.doi | 10.1016/j.addr.2017.12.018 | por |
dc.identifier.pmid | 29288732 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Drug Delivery Reviews | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ADDR-D-17-00158-R1_Manuscript.pdf | Author's Manuscript | 2,35 MB | Adobe PDF | Ver/Abrir |