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TitlePatterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture
Author(s)Neto, A. I.
Levkin, P. A.
Mano, J. F.
Keywords3D cell environments
Issue dateMar-2018
PublisherRoyal Society of Chemistry
JournalMaterials Horizons
CitationNeto A. I., Levkin P. A., Mano J. F. Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture, Materials Horizons, Vol. 5 , pp. 379-393, doi:10.1039/C7MH00877E, 2018
Abstract(s)Microarrays are a technological breakthrough for high-throughput screening of large numbers of assays. We review the evolution of microarray platforms for 3D cell culture to exhibit complex biological environments for tissue engineering, diagnostics and disease models. Patterned microarrays with extreme wettabilities were suggested as a versatile platform for high-throughput assays to generate 3D cell environments, as well as to characterize and analyze biomaterialsâ properties and cellâ cell and cellâ biomaterial interactions. Among the emerging HTS approaches, platforms with extreme wettabilities have the potential to revolutionize biomedical research, offering opportunities for drug screening on 3D cell based-systems with high reproducibility, versatility and spatial control. 
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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