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TitleSurface controlled biomimetic coating of polycaprolactone nanofiber mesh architectures
Author(s)Araujo, J. V.
Martins, A.
Leonor, I. B.
Pinho, E. D.
Reis, R. L.
Neves, N. M.
KeywordsBiomimetic coating
Electrospun nanofibers
Issue date2007
PublisherMary Ann Liebert
JournalTissue Engineering
CitationAraujo J. V., Martins A., Leonor I. B., Pinho E. D., Reis R. L., Neves N. M. Surface controlled biomimetic coating of polycaprolactone nanofiber mesh architectures, TISSUE ENGINEERING, Vol. 13, Issue 7, pp. 1759-1759, 2007.
Abstract(s)This work aims at developing novel electrospun nanofiber meshes coated with biomimetic calcium phosphate (BCP) mimicking the extracellular microenvironment found in the bone structure and not loosing the original morphology of the nanofibers. Poly(e- caprolactone) (PCL) was selected because of its current use in medical applications, biodegradability, biocompatibility and sus- ceptibility to partial hydrolysis by alkaline treatments. The deposition of a BCP layer, similar to the inorganic phase of bone, on PCL nanofiber meshes was achieved by a surface modi- fication. This initial surface modification was followed by treat- ments with solutions containing calcium and phosphate ions. The process was finished by the immersion in simulated body fluid (SBF) with 1.5
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AccessRestricted access (UMinho)
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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