Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58301

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dc.contributor.authorXavier, Sofia A.por
dc.contributor.authorVilas-Boas, Ricardopor
dc.contributor.authorBoal Carvalho, Pedropor
dc.contributor.authorMagalhães, Joana T.por
dc.contributor.authorMarinho, Carla M.por
dc.contributor.authorCotter, José Almeida Berkeleypor
dc.date.accessioned2019-01-16T16:17:57Z-
dc.date.available2019-07-01T06:02:11Z-
dc.date.issued2018-06-
dc.identifier.citationXavier, S. A., Vilas-Boas, R., Boal Carvalho, P., Magalhães, J. T., Marinho, C. M., & Cotter, J. B. (2018). Assessment of prognostic performance of Albumin–Bilirubin, Child–Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding. European journal of gastroenterology & hepatology, 30(6), 652-658por
dc.identifier.issn0954-691X-
dc.identifier.urihttp://hdl.handle.net/1822/58301-
dc.description.abstractThe Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores.por
dc.description.abstractObjective The Albumin–Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child–Pugh (CP) and Model for End-stage Liver Disease (MELD) scores. Patients and methods This was a retrospective unicentric study, including consecutive adult patients with cirrhosis admitted for UGIB between January 2011 and November 2015. Clinical, analytical, and endoscopic variables were assessed and ALBI, CP, and MELD scores at admission were calculated. Results This study included 111 patients. During the first 30 days of follow-up, 12 (10.8%) patients died, and during the first year of follow-up, another 10 patients died (first-year mortality of 19.8%). On comparing the three scores, for in-stay and 30-day mortality, only the ALBI score showed statistically significant results, with an area under the curve (AUC) of 0.80 (P<0.01) for both outcomes. For first-year mortality, AUC for ALBI, CP, and MELD scores were 0.71 (P<0.01), 0.64 (P<0.05), and 0.66 (P=0.02), respectively, whereas for global mortality, AUC were 0.75 (P<0.01), 0.72 (P<0.01), and 0.72 (P<0.01), respectively. On comparing the AUC of the three scores, no significant differences were found in first-year mortality and global mortality. Conclusion In our series, the ALBI score accurately predicted both in-stay and 30-day mortality, whereas CP and MELD scores could not predict these outcomes. All scores showed a fair prognostic prediction performance for first-year and global mortality. These results suggest that the ALBI score is particularly useful in the assessment of short-term outcomes, with a better performance than the most commonly used scores.por
dc.language.isoengpor
dc.publisherWolters Kluwer Healthpor
dc.rightsembargoedAccess (1 Year)por
dc.subjectAdultpor
dc.subjectAgedpor
dc.subjectAged, 80 and overpor
dc.subjectArea Under Curvepor
dc.subjectBilirubinpor
dc.subjectBiomarkerspor
dc.subjectCreatininepor
dc.subjectEsophageal and Gastric Varicespor
dc.subjectFemalepor
dc.subjectGastrointestinal Hemorrhagepor
dc.subjectHospital Mortalitypor
dc.subjectHumanspor
dc.subjectLiver Cirrhosispor
dc.subjectMalepor
dc.subjectMiddle Agedpor
dc.subjectPatient Admissionpor
dc.subjectPortugalpor
dc.subjectPredictive Value of Testspor
dc.subjectPrognosispor
dc.subjectProthrombin Timepor
dc.subjectROC Curvepor
dc.subjectReproducibility of Resultspor
dc.subjectRetrospective Studiespor
dc.subjectRisk Factorspor
dc.subjectSerum Albumin, Humanpor
dc.subjectSeverity of Illness Indexpor
dc.subjectTime Factorspor
dc.subjectDecision Support Techniquespor
dc.subjectModels, Biologicalpor
dc.subjectcirrhosispor
dc.subjectprognostic scorespor
dc.subjectupper gastrointestinal bleedingpor
dc.titleAssessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleedingpor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://journals.lww.com/eurojgh/Abstract/2018/06000/Assessment_of_prognostic_performance_of.10.aspxpor
oaire.citationStartPage652por
oaire.citationEndPage658por
oaire.citationIssue6por
oaire.citationVolume30por
dc.identifier.essn1473-5687-
dc.identifier.doi10.1097/MEG.0000000000001087por
dc.identifier.pmid29438135por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.subject.wosScience & Technologypor
sdum.journalEuropean Journal of Gastroenterology & Hepatologypor
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