Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58300

TitlePerianal Crohn's disease - association with significant inflammatory activity in proximal small bowel segments
Author(s)Xavier, Sofia
Cúrdia Gonçalves, Tiago
Dias de Castro, Francisca
Magalhães, Joana
Rosa, Bruno
Moreira, Maria João
Cotter, José Almeida Berkeley
KeywordsAdolescent
Adult
Animals
Anus Diseases
Capsule Endoscopy
Crohn Disease
Female
Humans
Inflammation
Intestine, Small
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Young Adult
Crohn's disease
small intestine
perianal disease
Issue date2018
PublisherTaylor & Francis
JournalScandinavian Journal of Gastroenterology
CitationXavier, S., Cúrdia Gonçalves, T., Dias de Castro, F., Magalhães, J., Rosa, B., Moreira, M. J., & Cotter, J. (2018). Perianal Crohn’s disease–association with significant inflammatory activity in proximal small bowel segments. Scandinavian journal of gastroenterology, 53(4), 426-429
Abstract(s)Perianal Crohn's disease (CD) prevalence varies according to the disease location, being particularly frequent in patients with colonic involvement. We aimed to evaluate small bowel involvement and compare small bowel capsule endoscopy findings and inflammatory activity between patients with and without perianal disease.
Objectives: Perianal Crohn’s disease (CD) prevalence varies according to the disease location, being particularly frequent in patients with colonic involvement. We aimed to evaluate small bowel involvement and compare small bowel capsule endoscopy findings and inflammatory activity between patients with and without perianal disease. Materials and methods: Retrospective single-center study including 71 patients – all patients with perianal CD (17 patients) who performed a small bowel capsule endoscopy were included, and non-perianal CD patients were randomly selected (54 patients). Clinical and analytical variables at diagnosis were reviewed. Statistical analysis was performed with SPSS v21.0 and a two-tailed p value <.05 was defined as indicating statistical significance. Results: Patients had a median age of 30 ± 16 years with 52.1% females. Perianal disease was present in 23.9%. Patients with perianal disease had significantly more relevant findings (94.1% vs 66.6%, p = .03) and erosions (70.6% vs 42.6%, p = .04), however, no differences were found between the two groups regarding ulcer, villous edema and stenosis detection. Overall, patients with perianal disease had more frequently significant small bowel inflammatory activity, defined as a Lewis Score ≥135 (94.1% vs 64.8%, p = .03), and higher Lewis scores in the first and second tertiles (450 ± 1129 vs 0 ± 169, p = .02 and 675 ± 1941 vs 0 ± 478, p = .04, respectively). No differences were found between the two groups regarding third tertile inflammatory activity assessed with the Lewis Score. Conclusion: Patients with perianal CD have significantly higher inflammatory activity in the small bowel, particularly in proximal small bowel segments, when compared with patients without perianal disease.
TypeArticle
URIhttp://hdl.handle.net/1822/58300
DOI10.1080/00365521.2018.1437928
ISSN0036-5521
e-ISSN1502-7708
Publisher versionhttps://www.tandfonline.com/doi/abs/10.1080/00365521.2018.1437928
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
xavier2018.pdf
  Restricted access
831,51 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID