Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58248

TitleNuclear migration in mammalian brain development
Author(s)Bertipaglia, Chiara
Gonçalves, João Carlos
Vallee, Richard Bert
KeywordsCentrosome
Cytoskeleton
Microtubules
Migration
Molecular motors
Nuclear envelope
Nucleus
Issue dateOct-2018
PublisherElsevier Ltd
JournalSeminars in Cell and Developmental Biology
Abstract(s)During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.
Typearticle
URIhttp://hdl.handle.net/1822/58248
DOI10.1016/j.semcdb.2017.11.033
ISSN1084-9521
Peer-Reviewedyes
AccessembargoedAccess (1 Year)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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