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TitleStrong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer
Author(s)Rabelo-Santos, Silvia Helena
Termini, Lara
Boccardo, Enrique
Derchain, Sophie
Longatto, Adhemar
Andreoli, Maria Antonieta
Costa, Maria Cecília
Lima Nunes, Rafaella Almeida
Lucci Ângelo-Andrade, Liliana Aparecida
Villa, Luisa Lina
Zeferino, Luiz Carlos
KeywordsHuman papillomavirus
Cervical intraepithelial neoplasia
Squamous cell carcinoma
Superoxide dismutase-2
Issue date24-Apr-2018
PublisherImpact Journals LLC
CitationRabelo-Santos, S. H., Termini, L., Boccardo, E., Derchain, S., Longatto-Filho, A., Andreoli, M. A., ... & Zeferino, L. C. (2018). Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer. Oncotarget, 9(31), 21630.
Abstract(s)It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%). There was no association between SOD2 expression and HPV 16 and/or 18 detection for every lesion analyzed. Binary Logist Regression revealed that strong SOD2 expression (OR: 27.50, 6.16-122.81) and HPV 16 and/or HPV 18 (OR: 12.67, 4.04-39.74) were independently more associated with CIN3 than non-neoplastic cervix. Strong SOD2 expression (OR: 3.30, 1.23-8.86) and HPV 16 and/or HPV 18 (OR: 3.51, 1.03-11.87) were independently more associated with ADC than SCC. Similar findings for SOD2 expression were observed by the Cochran Mantel-Haenszel test, controlling for HPV-16 and/or HPV 18. In conclusion, the expression of SOD2 was increased in CIN3 and SCC, and more increased in cervical ADC than in SCC. Strong SOD2 expression was statistically independent of the presence of HPV 16 and/or 18. These findings suggest that the mitochondrial antioxidant system and HPV infection could follow independent pathways in the carcinogenesis of cervical epithelium and in the differentiation to SCC or ADC of the cervix.
Publisher version[]=24850&path[]=77923
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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