Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58100

TitleHypersensitivity pneumonitis: antigen diversity and disease implications
Author(s)Nogueira, R.
Melo, N.
Bastos, Hélder Novais
Martins, N.
Delgado, L.
Morais, A.
Mota, P. C.
KeywordsAntigen
Diagnosis
Hypersensitivity pneumonitis
Prognosis
Research methods
Issue date2019
PublisherElsevier España
JournalPulmonology
Abstract(s)Hypersensitivity pneumonitis (HP) is an immune-mediated syndrome triggered by inhalation of a wide variety of allergens, to which an individual has previously been sensitized. More than 200 agents responsible for the disease have already been identified; however, HP occurs only in a small number of individuals exposed to causal antigens. The present report provides an overview of the role of antigen role in HP, highlighting its diversity, research methods, and prevention strategies, as well as the impact on disease prognosis following elimination of antigen. HP is an underdiagnosed disease and, therefore, it is difficult to accurately estimate its incidence. Triggering antigens can be divided into six broad categories: bacteria, fungi, mycobacteria, animal and plant proteins, chemicals, and metals, represented by disease prototypes. The identification of causal antigen is a major challenge; it is impossible to obtain in about 30-60% of cases. The acute form of HP, with early detection and immediate eviction of causal antigen, tends to have an excellent prognosis. In the chronic form, partial recovery of disease is still possible; however, some cases tend to progress to fibrosis, even after removal from exposure. In conclusion, HP diagnosis should be based on a proactive search for potential antigen sources, although their identification is hampered by the lack of standardized methods of demonstrating the specific antigen sensitization. Antigen avoidance is a critical determinant in disease prognosis.
TypeArticle
DescriptionArticle in Press
URIhttp://hdl.handle.net/1822/58100
DOI10.1016/j.pulmoe.2018.07.003
ISSN2531-0429
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Hypersensitivity pneumonitis Antigen diversity and disease implications..pdf1,28 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID