Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58099

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dc.contributor.authorInoue, Julianapor
dc.contributor.authorSilva, Miguelpor
dc.contributor.authorFofana, Bakarypor
dc.contributor.authorSanogo, Kassimpor
dc.contributor.authorMårtensson, Andreaspor
dc.contributor.authorSagara, Issakapor
dc.contributor.authorBjörkman, Anderspor
dc.contributor.authorVeiga, Maria Isabelpor
dc.contributor.authorFerreira, Pedro Eduardopor
dc.contributor.authorDjimde, Abdoulayepor
dc.contributor.authorGil, José Pedropor
dc.date.accessioned2019-01-11T16:09:27Z-
dc.date.available2019-01-11T16:09:27Z-
dc.date.issued2018-
dc.identifier.issn1080-6040por
dc.identifier.urihttp://hdl.handle.net/1822/58099-
dc.description.abstractDihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.por
dc.description.sponsorshipThis work was supported by a Swedish Research Council Grant (no. VR-2014-3134). The WANECAM study is funded by the European and Developing Countries Clinical Trial Partnership and by the Medicines for Malaria Venture (Geneva, Switzerland) and is co-funded by the United Kingdom Medical Research Councils, the Swedish International Development Cooperation Agency, the German Ministry for Education and Research, the University Claude Bernard (Lyon, France), the University of Science, Techniques, and Technologies of Bamako (Bamako, Mali), the Centre National de Recherche et de Formation sur le Paludisme (Burkina Faso), the Institut de Recherche en Sciences de la Sante (Bobo-Dioulasso, Burkina Faso), and the Centre National de Formation et de Recherche en Sante Rurale (Guinea).J.I. was supported by EuroInkaNet/Erasmus Mundus Program. Fundacao para a Ciencia e Tecnologia supports M.S. (grant no. SFRH/BD/129769/2017), M.I.V. (grant no. SFRH/BPD/76614/2011), and P.E.F. (grant no. IF/00143/2015).por
dc.language.isoengpor
dc.publisherCenters for Disease Control and Prevention (CDC)por
dc.relationSFRH/BD/129769/2017-
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F76614%2F2011/PT-
dc.rightsopenAccesspor
dc.titlePlasmodium falciparum Plasmepsin 2 Duplications, West Africapor
dc.typeletterToEditorpor
dc.peerreviewedyespor
oaire.citationStartPage1591por
oaire.citationEndPage1593por
oaire.citationIssue8por
oaire.citationVolume24por
dc.identifier.doi10.3201/eid2408.180370por
dc.identifier.pmid29798744por
dc.subject.wosScience & Technologypor
sdum.journalEmerging Infectious Diseasespor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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