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dc.contributor.authorInoue, Julianapor
dc.contributor.authorSilva, Miguelpor
dc.contributor.authorFofana, Bakarypor
dc.contributor.authorSanogo, Kassimpor
dc.contributor.authorMårtensson, Andreaspor
dc.contributor.authorSagara, Issakapor
dc.contributor.authorBjörkman, Anderspor
dc.contributor.authorVeiga, Maria Isabelpor
dc.contributor.authorFerreira, Pedro Eduardopor
dc.contributor.authorDjimde, Abdoulayepor
dc.contributor.authorGil, José Pedropor
dc.description.abstractDihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.por
dc.description.sponsorshipThis work was supported by a Swedish Research Council Grant (no. VR-2014-3134). The WANECAM study is funded by the European and Developing Countries Clinical Trial Partnership and by the Medicines for Malaria Venture (Geneva, Switzerland) and is co-funded by the United Kingdom Medical Research Councils, the Swedish International Development Cooperation Agency, the German Ministry for Education and Research, the University Claude Bernard (Lyon, France), the University of Science, Techniques, and Technologies of Bamako (Bamako, Mali), the Centre National de Recherche et de Formation sur le Paludisme (Burkina Faso), the Institut de Recherche en Sciences de la Sante (Bobo-Dioulasso, Burkina Faso), and the Centre National de Formation et de Recherche en Sante Rurale (Guinea).J.I. was supported by EuroInkaNet/Erasmus Mundus Program. Fundacao para a Ciencia e Tecnologia supports M.S. (grant no. SFRH/BD/129769/2017), M.I.V. (grant no. SFRH/BPD/76614/2011), and P.E.F. (grant no. IF/00143/2015).por
dc.publisherCenters for Disease Control and Prevention (CDC)por
dc.titlePlasmodium falciparum Plasmepsin 2 Duplications, West Africapor
dc.subject.wosScience & Technologypor
sdum.journalEmerging Infectious Diseasespor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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