Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/58076

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dc.contributor.authorFraga, Alexandra G.por
dc.contributor.authorBarbosa, Ana Margarida Martinspor
dc.contributor.authorFerreira, Catarina Machadopor
dc.contributor.authorFevereiro, Joãopor
dc.contributor.authorPedrosa, Jorgepor
dc.contributor.authorTorrado, Egídiopor
dc.date.accessioned2019-01-11T14:35:12Z-
dc.date.available2019-01-11T14:35:12Z-
dc.date.issued2018-
dc.identifier.issn1467-3037-
dc.identifier.urihttp://hdl.handle.net/1822/58076-
dc.description.abstractMycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies.por
dc.description.sponsorshipOur work is funded by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER); Infect-ERA grant BU_SPONT_HEAL; and the Fundação para a Ciência e Tecnologia (FCT) through the FCT investigator grant IF/01390/2014 to E.T. and the postdoctoral grant SFRH/BPD/112903/2015 to A.G.F.por
dc.language.isoengpor
dc.publisherCaister Academic Presspor
dc.rightsopenAccesspor
dc.subjectAdaptive Immunitypor
dc.subjectAnimalspor
dc.subjectCytokinespor
dc.subjectDendritic Cellspor
dc.subjectGene Expression Regulationpor
dc.subjectHumanspor
dc.subjectImmunity, Innatepor
dc.subjectMacrophagespor
dc.subjectMycobacteriumpor
dc.subjectMycobacterium tuberculosispor
dc.subjectNLR Proteinspor
dc.subjectPhagosomespor
dc.subjectSignal Transductionpor
dc.subjectT-Lymphocytespor
dc.subjectToll-Like Receptorspor
dc.subjectImmune Evasionpor
dc.titleImmune-evasion strategies of mycobacteria and their implications for the protective immune responsepor
dc.typearticlepor
dc.peerreviewedyespor
degois.publication.firstPage169por
degois.publication.lastPage198por
degois.publication.volume25por
dc.identifier.essn1467-3045-
dc.identifier.doi10.21775/cimb.025.169por
dc.identifier.pmc28875944por
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.subject.wosScience & Technologypor
sdum.journalCurrent Issues in Molecular Biologypor
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