Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58076
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Fraga, Alexandra G. | por |
dc.contributor.author | Barbosa, Ana Margarida Martins | por |
dc.contributor.author | Ferreira, Catarina Machado | por |
dc.contributor.author | Fevereiro, João | por |
dc.contributor.author | Pedrosa, Jorge | por |
dc.contributor.author | Torrado, Egídio | por |
dc.date.accessioned | 2019-01-11T14:35:12Z | - |
dc.date.available | 2019-01-11T14:35:12Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1467-3037 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58076 | - |
dc.description.abstract | Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies. | por |
dc.description.sponsorship | Our work is funded by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER); Infect-ERA grant BU_SPONT_HEAL; and the Fundação para a Ciência e Tecnologia (FCT) through the FCT investigator grant IF/01390/2014 to E.T. and the postdoctoral grant SFRH/BPD/112903/2015 to A.G.F. | por |
dc.language.iso | eng | por |
dc.publisher | Caister Academic Press | por |
dc.rights | openAccess | por |
dc.subject | Adaptive Immunity | por |
dc.subject | Animals | por |
dc.subject | Cytokines | por |
dc.subject | Dendritic Cells | por |
dc.subject | Gene Expression Regulation | por |
dc.subject | Humans | por |
dc.subject | Immunity, Innate | por |
dc.subject | Macrophages | por |
dc.subject | Mycobacterium | por |
dc.subject | Mycobacterium tuberculosis | por |
dc.subject | NLR Proteins | por |
dc.subject | Phagosomes | por |
dc.subject | Signal Transduction | por |
dc.subject | T-Lymphocytes | por |
dc.subject | Toll-Like Receptors | por |
dc.subject | Immune Evasion | por |
dc.title | Immune-evasion strategies of mycobacteria and their implications for the protective immune response | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 169 | por |
oaire.citationEndPage | 198 | por |
oaire.citationVolume | 25 | por |
dc.identifier.eissn | 1467-3045 | - |
dc.identifier.doi | 10.21775/cimb.025.169 | por |
dc.identifier.pmid | 28875944 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Current Issues in Molecular Biology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Bacterial Evasion 1P Chapter 7.pdf | 740,46 kB | Adobe PDF | Ver/Abrir |