Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/58076

TítuloImmune-evasion strategies of mycobacteria and their implications for the protective immune response
Autor(es)Fraga, Alexandra G.
Barbosa, Ana Margarida Martins
Ferreira, Catarina Machado
Fevereiro, João
Pedrosa, Jorge
Torrado, Egídio
Palavras-chaveAdaptive Immunity
Animals
Cytokines
Dendritic Cells
Gene Expression Regulation
Humans
Immunity, Innate
Macrophages
Mycobacterium
Mycobacterium tuberculosis
NLR Proteins
Phagosomes
Signal Transduction
T-Lymphocytes
Toll-Like Receptors
Immune Evasion
Data2018
EditoraCaister Academic Press
RevistaCurrent Issues in Molecular Biology
Resumo(s)Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies.
Tipoarticle
URIhttp://hdl.handle.net/1822/58076
DOI10.21775/cimb.025.169
ISSN1467-3037
e-ISSN1467-3045
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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Bacterial Evasion 1P Chapter 7.pdf740,46 kBAdobe PDFVer/Abrir

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