Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/57999
Título: | The chemokine receptor CXCR3 promotes CD8+ T cell accumulation in uninfected salivary glands but Is not necessary after Murine Cytomegalovirus infection |
Autor(es): | Caldeira-Dantas, Sofia Furmanak, Thomas Smith, Corinne Quinn, Michael Teos, Leyla Y. Ertel, Adam Kurup, Drishya Tandon, Mayank Alevizos, Ilias Snyder, Christopher M. |
Palavras-chave: | Animals CD8-Positive T-Lymphocytes Cell Movement Cells, Cultured Chemokines Herpesviridae Infections Immunologic Memory Integrin alpha4 Interferon-gamma Mice Mice, Inbred C57BL Mice, Knockout Muromegalovirus Receptors, CCR5 Receptors, CXCR3 Salivary Glands |
Data: | 2018 |
Editora: | American Association of Immunologists (AAI) |
Revista: | The Journal of Immunology |
Citação: | Caldeira-Dantas, S., Furmanak, T., et. al. (2018). The chemokine receptor CXCR3 promotes CD8+ T cell accumulation in uninfected salivary glands but is not necessary after murine cytomegalovirus infection. The Journal of Immunology, 200(3), 1133-1145 |
Resumo(s): | Recent work indicates that salivary glands are able to constitutively recruit CD8+ T cells and retain them as tissue-resident memory T cells, independently of local infection, inflammation, or Ag. To understand the mechanisms supporting T cell recruitment to the salivary gland, we compared T cell migration to the salivary gland in mice that were infected or not with murine CMV (MCMV), a herpesvirus that infects the salivary gland and promotes the accumulation of salivary gland tissue-resident memory T cells. We found that acute MCMV infection increased rapid T cell recruitment to the salivary gland but that equal numbers of activated CD8+ T cells eventually accumulated in infected and uninfected glands. T cell recruitment to uninfected salivary glands depended on chemokines and the integrin α4 Several chemokines were expressed in the salivary glands of infected and uninfected mice, and many of these could promote the migration of MCMV-specific T cells in vitro. MCMV infection increased the expression of chemokines that interact with the receptors CXCR3 and CCR5, but neither receptor was needed for T cell recruitment to the salivary gland during MCMV infection. Unexpectedly, however, the chemokine receptor CXCR3 was critical for T cell accumulation in uninfected salivary glands. Together, these data suggest that CXCR3 and the integrin α4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after MCMV infection. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57999 |
DOI: | 10.4049/jimmunol.1701272 |
ISSN: | 0022-1767 |
e-ISSN: | 1550-6606 |
Versão da editora: | http://www.jimmunol.org/content/200/3/1133 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Caldeira-Dantas 2018.pdf | 1,14 MB | Adobe PDF | Ver/Abrir |